BME-475-davidlin-2026-09-17-03-45-37
Title of Course: Bioreactor Design and Separations
Prefix and Number: BME 475
Semester and Year: tbd
Number of Credit Hours: 3
Prerequisites: BME 455 with C or better
Course Details
Day and Time: tbd
Meeting Location: tbd
Instructor Contact Information
Instructor Name: tbd
Instructor Contact Information: tbd
Instructor Office Hours: tbd
TA Name: tbd
TA Contact Information: tbd
TA Office Hours: tbd
Course Description
Introduction to bioreactor design and operation and processes for separations of bioproducts.
Course Materials
Books: Bioprocess Engineering: Kinetics, Biosystems, Sustainability, and Reactor Design, S.J. Liu. Elsevier, 2012; E-book cost: $165
Other Materials: none
Fees: none
|
Course Learning Outcomes (students will be able to:) |
Activities Supporting the Learning Outcomes | Assessment of the Learning Outcomes |
|---|---|---|
| Understand the fundamentals of chemical kinetics, batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering and bioprocess systems engineering. | Lecture, homework, exams, project | Homeworks, exams, project |
| Understand the analysis, optimization, selection of cultivation methods. | Lecture, homework, exams, project | Homeworks, exams, project |
| Understand the design and consistent control over molecular biological and chemical transformations. | Lecture, homework, exams, project | Homeworks, exams, project |
| Dates | Lesson Topic | Assignment | Assessment |
|---|---|---|---|
|
Week 1 |
Syllabus, course overview, and expectations. Introduction to biological process and biotechnology applications |
Lecture |
|
|
Week 2 |
Chemical from Metabolic Pathways |
Lecture, homework, quiz |
homework, quiz |
|
Week 3 |
Elemental and Redox Balances |
Lecture |
|
|
Week 4 |
Thermodynamics of Bioreactions |
Lecture, homework, quiz |
homework, quiz |
|
Week 5 |
Biochemical Reaction Networks |
Lecture, exam |
Exam |
|
Week 6 |
Enzyme Kinetics and Metabolic Control Analysis |
Lecture, homework, quiz |
homework, quiz |
|
Week 7 |
How Cells Grow |
Lecture |
|
|
Week 8 |
Growth Kinetics of Cell Cultures |
Lecture, homework, quiz |
homework, quiz |
|
Week 9 |
Population Balance Equations |
Lecture, exam |
Exam |
|
Week 10 |
Design of Fermentation Processes; project selections |
Lecture, homework, project, quiz |
homework, quiz |
|
Week 11 |
Gas-Liquid Mass Transfer |
Lecture, project |
Preliminary Project report |
|
Week 12 |
Bioprocess safety |
Lecture, homework, project, quiz |
homework, quiz |
|
Week 13 |
Bioreactor Design and Operation |
Lecture, project |
Preliminary Project report |
|
Week 14 |
Scale-up of Bioprocesses |
Lecture, homework, project, quiz |
homework, quiz |
|
Week 15 |
Project presentations |
Project |
Project and final exam |
Expectations for Student Effort
For each hour of lecture equivalent, students should expect to have a minimum of two hours of work outside of class.
Grading
| Type of Assignment (tests, papers, etc) | Points | Percent of Overall Grade |
|---|---|---|
| Homework | 20% | |
| Exams | 40% | |
| Project | 25% | |
| Quizzes | 15% |
| Grade | Percent | Grade | Percent |
|---|---|---|---|
| A |
>92 |
C | 73-76 |
| A- | 90-91 | C- | 70-72 |
| B+ | 87-89 | D+ | 67-69 |
| B | 83-86 | D | 60-66 |
| B- | 80-82 | F | <60 |
| C+ | 77-79 |
Percentage grades will be rounded to the nearest tenth of a percentage point.
Attendance and Make-Up Policy
Students should make all reasonable efforts to attend all class meetings. However, in the event a student is unable to attend a class, it is the responsibility of the student to inform the instructor as soon as possible, explain the reason for the absence (and provide documentation, if appropriate), and make up class work missed within a reasonable amount of time, if allowed. Missing class meetings may result in reducing the overall grade in the class.
Academic Integrity Statement
You are responsible for reading WSU's Academic Integrity Policy, which is based on Washington State law. If you cheat in your work in this class you will:
-Receive an "F" as the course grade
-Be reported to the Center for Community Standards
-Have the right to appeal my decision
-Not be able to drop the course of withdraw from the course until the appeals process is finished
If you have any questions about what you can and cannot do in this course, ask me.
If you want to ask for a change in my decision about academic integrity, use the form at the Center for Community Standards website. You must submit this request within 21 calendar days of the decision.