BME-420-davidlin-2026-09-08-06-09-54
Title of Course: Dynamics in Physiological Systems
Prefix and Number: BME 420
Semester and Year: tbd
Number of Credit Hours: 4
Prerequisites: BME 322
Course Details
Day and Time: tbd
Meeting Location: tbd
Instructor Contact Information
Instructor Name: tbd
Instructor Contact Information: tbd
Instructor Office Hours: tbd
TA Name: tbd
TA Contact Information: tbd
TA Office Hours: tbd
Course Description
Modeling of dynamic systems applied to physiological systems and introduction to feedback control. Topics include neural, endocrine, and metabolic systems and homeostasis.
Course Materials
Books: Human Physiology: An Integrated Approach, 8th Edition; $64.98
Other Materials: none
Fees: none
|
Course Learning Outcomes (students will be able to:) |
Activities Supporting the Learning Outcomes | Assessment of the Learning Outcomes |
|---|---|---|
|
Mathematically describe relationships between biological structure and physiological function using linear, nonlinear, and/or differential equations. |
Lecture, lab, homework, in-class activities | Homework, exams, lab reports |
|
Formulate mathematical models for major physiological systems. |
Lecture, lab, homework, in-class activities | Homework, exams, lab reports |
|
Apply mathematical models for engineering analysis of major physiological systems. |
Lecture, lab, homework, in-class activities |
Homework, exams, lab reports |
|
Use appropriate computational analysis tools, such as Simulink. |
Lecture, lab, homework, in-class activities |
Homework, exams, lab reports |
|
Analyze and interpret physiological data using engineering principles to address problems in quantitative physiology. |
Lecture, lab, homework, in-class activities |
Homework, exams, lab reports |
|
Conduct experiments to measure physiological functions and apply quantitative techniques to estimate unmeasurable functions. |
Lecture, lab, homework, in-class activities |
Homework, lab reports |
| Dates | Lesson Topic | Assignment | Assessment |
|---|---|---|---|
|
Week 1 |
Syllabus, course overview, and expectations. Definition of homeostasis |
Lecture, lab |
Lab report |
|
Week 2 |
Developing differential equations using modeling 1st order material balances: Body fluid compartment dynamics |
Lecture, homework, lab |
Lab report, homework |
|
Week 3 |
Natural and forced responses for 1st order systems |
Lecture, homework, lab |
Lab report, homework |
|
Week 4 |
2nd order material balances: chemical kinetics |
Lecture, homework, lab |
Lab report, homework |
|
Week 5 |
Natural and forced responses for 2nd order systems |
Lecture, homework, lab |
Lab report, homework |
|
Week 6 |
Laplace and frequency domain. |
Lecture, exam |
Exam |
|
Week 7 |
Impedance, Transfer functions and time constants |
Lecture, homework, lab |
Lab report, homework |
|
Week 8 |
Sinusoidal steady-state analysis |
Lecture, homework, lab |
Lab report, homework |
|
Week 9 |
Definition of feedback systems |
Lecture, exam |
Exam |
|
Week 10 |
Block diagram models |
Lecture, homework, lab |
Lab report, homework |
|
Week 11 |
Block diagram reduction and transfer functions |
Lecture, homework, lab |
Lab report, homework |
|
Week 12 |
Pole-zero diagrams |
Lecture, homework, lab |
Lab report, homework |
|
Week 13 |
Closed-loop stability |
Lecture, homework, lab |
Lab report, homework |
|
Week 14 |
Time-delays |
Lecture, homework, lab |
Lab report, homework |
|
Week 15 |
Nyquist stability |
Lecture, homework, lab |
Lab report, homework |
Expectations for Student Effort
For each hour of lecture equivalent, students should expect to have a minimum of two hours of work outside of class.
Grading
| Type of Assignment (tests, papers, etc) | Points | Percent of Overall Grade |
|---|---|---|
| Exams (2) | 30% (15% each) | |
| Final | 20% | |
| Homework | 20% | |
| Lab reports | 20% | |
| In-class activities | 10% |
| Grade | Percent | Grade | Percent |
|---|---|---|---|
| A |
>92 |
C | 73-76 |
| A- | 90-91 | C- | 70-72 |
| B+ | 87-89 | D+ | 67-69 |
| B | 83-86 | D | 60-66 |
| B- | 80-82 | F | <60 |
| C+ | 77-79 |
Numerical grades will be rounded to the nearest integer value.
Attendance and Make-Up Policy
Students should make all reasonable efforts to attend all class meetings. However, in the event a student is unable to attend a class, it is the responsibility of the student to inform the instructor as soon as possible, explain the reason for the absence (and provide documentation, if appropriate), and make up class work missed within a reasonable amount of time, if allowed. Missing class meetings may result in reducing the overall grade in the class.
Academic Integrity Statement
You are responsible for reading WSU's Academic Integrity Policy, which is based on Washington State law. If you cheat in your work in this class you will:
-Receive an "F" for the course grade
-Be reported to the Center for Community Standards
-Have the right to appeal my decision
-Not be able to drop the course of withdraw from the course until the appeals process is finished
If you have any questions about what you can and cannot do in this course, ask me.
If you want to ask for a change in my decision about academic integrity, use the form at the Center for Community Standards website. You must submit this request within 21 calendar days of the decision.